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Gene information
Official symbol
CYP2C19
Official full name
cytochrome P450 family 2 subfamily C member 19
Gene type
protein-coding gene
Chromosome
10q23.33
Alias symbol
P450IIC19; CPCJ
Previous symbol
CYP2C
Gene family
Cytochrome P450 family 2
Resources
Entrez Gene
1557
HGNC
HGNC:2621
Ensembl
ENSG00000165841
Vega
OTTHUMG00000018799
UCSC
uc010qnz.3
GO terms: 27 records
GO
Description
Category
LogP
Number of genes
Detail
GO:0001676
long-chain fatty acid metabolic process
GO Biological Processes
-13.6883394
17
More
GO:0004497
monooxygenase activity
GO Molecular Functions
-11.8172125
15
More
GO:0005506
iron ion binding
GO Molecular Functions
-10.4063739
16
More
GO:0006631
fatty acid metabolic process
GO Biological Processes
-20.3287405
33
More
GO:0006690
icosanoid metabolic process
GO Biological Processes
-21.0788451
23
More
GO:0006720
isoprenoid metabolic process
GO Biological Processes
-5.01065294
9
More
GO:0006721
terpenoid metabolic process
GO Biological Processes
-4.89883771
15
More
GO:0006805
xenobiotic metabolic process
GO Biological Processes
-8.19045514
12
More
GO:0008202
steroid metabolic process
GO Biological Processes
-19.3229835
29
More
GO:0008395
steroid hydroxylase activity
GO Molecular Functions
-9.29772341
9
More
GO:0009410
response to xenobiotic stimulus
GO Biological Processes
-32.6021211
82
More
GO:0016098
monoterpenoid metabolic process
GO Biological Processes
-6.54368931
4
More
GO:0016491
oxidoreductase activity
GO Molecular Functions
-14.1519969
39
More
GO:0016705
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO Molecular Functions
-11.3284001
18
More
GO:0016712
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO Molecular Functions
-13.5752504
12
More
GO:0019369
arachidonic acid metabolic process
GO Biological Processes
-15.7454969
15
More
GO:0019373
epoxygenase P450 pathway
GO Biological Processes
-8.85891522
7
More
GO:0019825
oxygen binding
GO Molecular Functions
-4.96169199
6
More
GO:0020037
heme binding
GO Molecular Functions
-15.4577568
20
More
GO:0032787
monocarboxylic acid metabolic process
GO Biological Processes
-19.1871601
38
More
GO:0033559
unsaturated fatty acid metabolic process
GO Biological Processes
-16.8056258
19
More
GO:0042178
xenobiotic catabolic process
GO Biological Processes
-7.90595898
7
More
GO:0046906
tetrapyrrole binding
GO Molecular Functions
-14.8570803
20
More
GO:0070330
aromatase activity
GO Molecular Functions
-7.90595898
7
More
GO:0071466
cellular response to xenobiotic stimulus
GO Biological Processes
-9.33788411
28
More
GO:0097267
omega-hydroxylase P450 pathway
GO Biological Processes
-9.26986898
6
More
GO:0120254
olefinic compound metabolic process
GO Biological Processes
-12.8805599
18
More
KEGG pathways: 5 records
KEGG
Description
Category
LogP
Number of genes
Detail
hsa00590
Arachidonic acid metabolism
KEGG Pathway
-11.1782370
12
More
hsa00591
Linoleic acid metabolism
KEGG Pathway
-5.99805120
6
More
hsa00982
Drug metabolism - cytochrome P450
KEGG Pathway
-7.86918833
10
More
hsa04726
Serotonergic synapse
KEGG Pathway
-8.91693578
13
More
hsa05204
Chemical carcinogenesis - DNA adducts
KEGG Pathway
-6.89688307
9
More
Drug-Gene interaction
view
Related drugs: 470 records
Drug name
Interaction type
Source
PMID
View
(-)-u-50488
DTC
view
(r)-felodipine
DTC
view
(r)-flecainide
DTC
view
(r)-nitrendipine
DTC
view
(r)-pinocembrin
DTC
view
(r,s)-indatraline
DTC
view
(s)-alaproclate
DTC
view
(s)-ampa
DTC
view
(s)-felodipine
DTC
view
(s)-isradipine
DTC
view
(s)-nimodipine
DTC
view
(s)-nitrendipine
DTC
view
1r,9s-hydrastine
DTC
view
4-chloromercuribenzoic acid
DTC
view
6-o-benzylguanine
DTC
view
acacetin
DTC
view
acetaminophen
DTC
22931300
view
allopurinol
DTC
22931300
view
alpha-naphthoflavone
DTC
view
alprostadil
DTC
22931300
view
ambrisentan
PharmGKB
25286744
view
amiodarone
DTC
22931300
view
amitriptylinoxide
DTC
view
amoxicillin
DTC
22931300
view
amsacrine
DTC
22931300
view
anabasine
DTC
view
aniracetam
DTC
view
apigenin
DTC
view
arasertaconazole
DTC
view
arbaclofen
DTC
view
asarinin
DTC
view
atazanavir
PharmGKB
view
atorvastatin
PharmGKB
24140730
view
aurintricarboxylic acid
DTC
view
azathioprine
DTC
22931300
view
azithromycin
DTC
22931300
view
aztreonam
DTC
22931300
view
baicalein
DTC
view
beclomethasone
DTC
22931300
view
bergamottin
DTC
view
bergapten
DTC
view
beta-ccm
DTC
view
biochanin
DTC
view
bradanicline
DTC
23126648
view
brilliant green oxalate
DTC
view
brivaracetam
PharmGKB
FDA
24717838
view
budesonide
DTC
22931300
view
busulfan
DTC
PharmGKB
24192117
22931300
24165757
view
butorphanol
DTC
22931300
view
butylated hydroxytoluene
DTC
22931300
view
butylparaben
DTC
view
caffeine
DTC
22931300
view
camptothecin
DTC
view
capensin
DTC
view
capsazepine
DTC
view
carbamazepine
DTC
PharmGKB
22931300
view
carbimazole
DTC
22931300
view
carisoprodol
FDA
view
carmustine
DTC
22931300
view
cefoperazone
DTC
22931300
view
ceftriaxone
DTC
22931300
view
chelerythrine
DTC
view
chembl1079460
DTC
view
chembl1169388
DTC
view
chembl120806
DTC
view
chembl1214274
DTC
view
chembl123904
DTC
view
chembl1256364
DTC
view
chembl1256697
DTC
view
chembl1256851
DTC
view
chembl1257081
DTC
view
chembl1269022
DTC
view
chembl1270168
DTC
view
chembl1288013
DTC
view
chembl1288014
DTC
view
chembl1310701
DTC
view
chembl1317986
DTC
view
chembl1320453
DTC
view
chembl1334465
DTC
view
chembl1339015
DTC
view
chembl1342336
DTC
view
chembl1343568
DTC
view
chembl1358137
DTC
view
chembl1370698
DTC
view
chembl1371696
DTC
view
chembl1420370
DTC
view
chembl145725
DTC
view
chembl1513392
DTC
view
chembl1548739
DTC
view
chembl157946
DTC
view
chembl159096
DTC
view
chembl16751
DTC
view
chembl180966
DTC
view
chembl188641
DTC
view
chembl2094549
DTC
view
chembl238624
DTC
view
chembl239439
DTC
view
chembl242171
DTC
view
chembl242172
DTC
view
chembl242385
DTC
view
chembl244707
DTC
view
chembl250053
DTC
view
chembl258465
DTC
view
chembl27006
DTC
view
chembl271165
DTC
view
chembl272005
DTC
view
chembl27403
DTC
view
chembl275311
DTC
view
chembl277863
DTC
view
chembl285932
DTC
view
chembl287689
DTC
view
chembl29197
DTC
view
chembl294747
DTC
view
chembl306764
DTC
view
chembl323356
DTC
view
chembl327980
DTC
view
chembl335741
DTC
view
chembl336095
DTC
view
chembl34730
DTC
view
chembl35482
DTC
view
chembl362223
DTC
view
chembl362863
DTC
view
chembl372797
DTC
view
chembl375270
DTC
view
chembl384903
DTC
view
chembl406845
DTC
view
chembl421215
DTC
view
chembl429095
DTC
view
chembl434063
DTC
view
chembl45349
DTC
17266205
view
chembl469309
DTC
view
chembl471005
DTC
view
chembl471225
DTC
view
chembl476501
DTC
view
chembl476833
DTC
view
chembl512832
DTC
view
chembl512908
DTC
view
chembl515505
DTC
view
chembl530733
DTC
view
chembl533542
DTC
view
chembl53898
DTC
view
chembl546597
DTC
view
chembl547407
DTC
view
chembl552439
DTC
view
chembl584854
DTC
view
chembl584860
DTC
view
chembl585045
DTC
view
chembl587259
DTC
view
chembl587849
DTC
view
chembl591613
DTC
view
chembl592561
DTC
view
chembl601110
DTC
view
chembl601135
DTC
view
chembl601616
DTC
view
chembl606167
DTC
view
chembl71294
DTC
view
chembl72410
DTC
view
chembl79140
DTC
view
chembl83899
DTC
view
chembl85194
DTC
view
chembl86931
DTC
view
chembl88147
DTC
view
chembl88272
DTC
view
chembl93655
DTC
view
chloramphenicol
PharmGKB
view
chloroguanide
PharmGKB
10471063
view
chloropyramine
DTC
view
chloroquine
DTC
22931300
view
chlorpromazine hydrochloride
DTC
view
chlorpropamide
DTC
22931300
view
chrysin
DTC
view
cilostazol
DTC
22931300
view
cimetidine
DTC
PharmGKB
view
ciprofloxacin
DTC
22931300
view
citalopram
FDA
view
clarithromycin
DTC
22931300
view
clemastine
DTC
view
clemizole
DTC
view
clobazam
FDA
view
clobenpropit
DTC
view
clofibrate
DTC
22931300
view
clomethiazole
DTC
view
clonidine
DTC
view
clopidogrel
DTC
FDA
view
clorgiline
DTC
view
clotrimazole
DTC
22931300
view
clozapine
DTC
PharmGKB
28664816
22931300
view
colchicine
DTC
22931300
view
coumarin
DTC
22931300
view
cp-339818
DTC
view
cromolyn
DTC
22931300
view
cyc-116
DTC
20462263
view
cyclophosphamide
DTC
22931300
view
cyclosporine
DTC
22931300
view
cyproterone
DTC
22931300
view
cytarabine
DTC
22931300
view
dacarbazine
DTC
22931300
view
daidzein
DTC
view
dantrolene
DTC
22931300
view
deguelin
DTC
view
dexamethasone
DTC
22931300
view
dexlansoprazole
PharmGKB
FDA
22455762
view
dexmedetomidine
DTC
view
diazepam
FDA
view
diclofenac
DTC
22931300
view
didanosine
DTC
22931300
view
diethylstilbestrol
DTC
22931300
view
diflufenican
DTC
view
digoxin
DTC
22931300
view
dihydrocapsaicin
DTC
view
dihydroxidine
DTC
view
diltiazem
DTC
22931300
view
dioxybenzone
DTC
view
diphenhydramine
DTC
22931300
view
diphenyleneiodonium
DTC
view
dipyridamole
DTC
view
dipyrone
PharmGKB
25241292
view
disulfiram
DTC
22931300
view
docebenone
DTC
view
dofetilide
DTC
22931300
view
doxepin
PharmGKB
FDA
12360109
23486447
view
doxorubicin
DTC
PharmGKB
29938344
22931300
20179710
view
drospirenone
FDA
view
dup-697
DTC
view
e324
DTC
view
ebselen
DTC
view
ecadotril
DTC
view
efavirenz
PharmGKB
view
ellagic acid
DTC
view
elliptecine
DTC
view
emodin
DTC
view
enoxolone
DTC
22931300
view
erlosamide
PharmGKB
FDA
view
erythromycin
DTC
22931300
view
escitalopram
DTC
FDA
view
esomeprazole
FDA
view
esoxybutynin
DTC
view
estradiol
DTC
22931300
view
ethambutol
PharmGKB
view
ethinyl estradiol
DTC
22931300
view
etidronic acid
DTC
22931300
view
etoposide
DTC
22931300
view
etravirine
PharmGKB
23111422
view
felbamate
DTC
PharmGKB
22931300
view
fenofibrate
DTC
view
fenticlor
DTC
view
finasteride
DTC
22931300
view
fipexide
DTC
view
flibanserin
PharmGKB
FDA
view
floxuridine
DTC
22931300
view
fluconazole
DTC
22931300
view
flumazenil
DTC
view
flunisolide
DTC
22931300
view
flunitrazepam
PharmGKB
view
fluorouracil
PharmGKB
view
flutamide
DTC
22931300
view
fluvastatin
PharmGKB
view
fluvoxamine
DTC
22931300
view
formoterol
PharmGKB
FDA
view
gabazine
DTC
view
galangin
DTC
view
genistein
DTC
view
gentamicin
DTC
22931300
view
glabranin
DTC
view
glafenine
DTC
22931300
view
glyburide
DTC
view
glycine
DTC
22931300
view
gr-127935
DTC
view
gs-39783
DTC
view
guanfacine
DTC
view
gyki-52466
DTC
view
hesperetin
DTC
view
homatropine methylbromide
DTC
22931300
view
hycanthone
DTC
22931300
view
hydralazine
DTC
22931300
view
hydrastine
DTC
view
hydroxyzine
DTC
22931300
view
ibuprofen
DTC
PharmGKB
25502615
22931300
view
ici-199,441
DTC
view
icillin
DTC
view
icotinib
PharmGKB
25995169
22585284
view
imipramine
DTC
22931300
view
inamrinone
DTC
view
indinavir
DTC
22931300
view
indirubin-3-monoxime
DTC
view
indomethacin
DTC
PharmGKB
22931300
view
iodomelatonin
DTC
view
iproniazid
DTC
22931300
view
ipsapirone
DTC
view
isoboldine
DTC
view
isoliquiritigenin
DTC
view
isoniazid
PharmGKB
16248836
view
karanjin
DTC
view
ketanserin
DTC
view
ketoconazole
DTC
22931300
view
l-694247
DTC
view
l-732138
DTC
view
labetalol
DTC
PharmGKB
22931300
23090703
view
lamotrigine
DTC
22931300
view
lansoprazole
DTC
FDA
view
lansoprazole sulfide
DTC
view
lapachone
DTC
view
leucine
DTC
22931300
view
leuprolide
DTC
22931300
view
linopirdine
DTC
view
liothyronine
DTC
22931300
view
loratadine
DTC
view
lovastatin
DTC
PharmGKB
22931300
view
luzindole
DTC
view
mangostin
DTC
view
mefenamic acid
DTC
22931300
view
menadione
DTC
view
mephobarbital
PharmGKB
15499191
view
mepivacaine
DTC
22931300
view
mercaptopurine
DTC
22931300
view
mesalamine
DTC
view
mestranol
DTC
22931300
view
metaraminol
DTC
22931300
view
methotrexate
DTC
22931300
view
methyldopa
DTC
22931300
view
metyrosine
DTC
22931300
view
miconazole
DTC
view
midodrine
DTC
22931300
view
minocycline
DTC
22931300
view
minoxidil
DTC
22931300
view
mirtazapine
DTC
view
mitomycin
DTC
22931300
view
moclobemide
PharmGKB
view
modafinil
DTC
PharmGKB
22931300
view
monastrol
DTC
view
mono-n-acetyl dapsone
DTC
view
montelukast
DTC
22931300
view
myricetin
DTC
view
n,n-hexamethyleneamiloride
DTC
view
n-desmethylclozapine
PharmGKB
28664816
view
naproxen
DTC
22931300
view
naringenin
DTC
view
nateglinide
DTC
22931300
view
nb-acetyltryptamine
DTC
view
nelfinavir
PharmGKB
16267764
25752914
view
neostigmine bromide
DTC
22931300
view
nevirapine
DTC
PharmGKB
22931300
21860339
view
niacin
DTC
22931300
view
nicorandil
DTC
view
nifedipine
DTC
22931300
view
niguldipine
DTC
view
nilutamide
DTC
22931300
view
nimesulide
DTC
22931300
view
nisoldipine
DTC
22931300
view
nitrofurantoin
DTC
22931300
view
nordihydroguaiaretic acid
DTC
view
norethindrone
PharmGKB
view
noscapine
DTC
view
ns-398
DTC
view
ofloxacin
DTC
22931300
view
oleoyl dopamine
DTC
view
omeprazole
DTC
FDA
view
oxazepam
PharmGKB
view
oxotremorine
DTC
view
pantoprazole
FDA
view
papaverine
DTC
view
perhexiline
DTC
22931300
view
pf-03715455
DTC
21888439
view
phenazepam
PharmGKB
30325732
view
phenelzine
DTC
view
phenobarbital
DTC
PharmGKB
22931300
23551241
view
phenprocoumon
PharmGKB
21636598
view
phentolamine
DTC
view
phenyl biguanide
DTC
view
phenylbutazone
DTC
22931300
view
phenytoin
DTC
FDA
22931300
view
phloretin
DTC
view
pifexole
DTC
view
pimozide
DTC
view
piribedil
DTC
view
piroxicam
DTC
22931300
view
plicamycin
DTC
22931300
view
pomiferin
DTC
view
prasugrel
FDA
view
prednisone
PharmGKB
view
prochlorperazine
DTC
22931300
view
progesterone
DTC
PharmGKB
22931300
31482508
view
propranolol
DTC
22931300
view
propylpyrazoletriol
DTC
view
propylthiouracil
DTC
22931300
view
pseudoephedrine
DTC
view
psoralen
DTC
view
pyrazinamide
DTC
PharmGKB
22931300
view
pyrilamine
DTC
22931300
view
pyrrolidine dithiocarbamate
DTC
view
quercetin
DTC
view
quetiapine
PharmGKB
25025989
view
quinidine
DTC
19117415
view
quinoxaline1
DTC
view
rabeprazole
FDA
view
raclopride
DTC
view
raloxifene
DTC
22931300
view
ranitidine
DTC
22931300
view
rel-cisapride
DTC
22931300
view
remoxipride
DTC
22931300
view
resokaempferol
DTC
view
rifampin
DTC
PharmGKB
22931300
view
rimcazole
DTC
view
risperidone
PharmGKB
25042870
view
ro-194603
DTC
view
rotenone
DTC
view
rucaparib
PharmGKB
view
s-etomidate
DTC
view
salagen
DTC
view
sanguinarium
DTC
view
sb-202190
DTC
view
sb-203580
DTC
view
sb-216763
DTC
view
sb-222200
DTC
view
sb-224289
DTC
view
sb-431542
DTC
view
sc-560
DTC
view
selegiline
DTC
22931300
view
silver sulfadiazine
DTC
view
simeprevir
PharmGKB
view
simvastatin
DTC
PharmGKB
22931300
view
skimmianine
DTC
view
sotalol
DTC
22931300
view
spermine
DTC
view
spiperone
DTC
view
splitomicin
DTC
view
sr-2640
DTC
view
stavudine
DTC
22931300
view
sulfadoxine
DTC
22931300
view
sulfaphenazole
DTC
22931300
view
sulindac
DTC
22931300
view
sulpiride
DTC
22931300
view
tamoxifen citrate
DTC
view
tarenflurbil
DTC
view
techtochrysin
DTC
view
telenzepine
DTC
view
temazepam
PharmGKB
view
terazosin
DTC
22931300
view
tesmilifene
DTC
view
testosterone
DTC
22931300
view
tetracycline
DTC
22931300
view
thalidomide
PharmGKB
31124417
view
thioperamide
DTC
view
ticagrelor
PharmGKB
FDA
26151596
view
ticlopidine
DTC
view
tolbutamide
PharmGKB
10022751
10411572
view
tolnaftate
DTC
view
tolterodine
PharmGKB
view
topiramate
PharmGKB
view
torsemide
DTC
22931300
view
tpck
DTC
view
triamcinolone
DTC
22931300
view
trifluoperazine
DTC
view
trimethoprim
DTC
22931300
view
trimipramine
PharmGKB
18677622
20531370
8563772
14520122
17625515
12222994
11452243
20083681
8195181
15168101
16413245
20492469
9316174
7969038
10774635
19884907
8835703
23486447
21412232
view
troglitazone
DTC
22931300
view
tyrphostin 47
DTC
view
tyrphostin ag 879
DTC
view
urapidil
DTC
view
valproic acid
DTC
22931300
view
vanoxerine
DTC
view
voriconazole
FDA
view
warfarin
PharmGKB
19752777
18574025
8723744
21692828
23941071
25652102
27356304
view
win-552122
DTC
view
zafirlukast
DTC
22931300
view
zardaverine
DTC
view
zidovudine
DTC
22931300
view
zileuton
DTC
22931300
view
zoxazolamine
DTC
22931300
view
zucapsaicin
DTC
view
Related studies: 21 records
Molecular factor
Omics type
Application
Objective
MI type
Reference
NM_000769.4:c.[681G>A;636G>A]
genomics
clopidogrel[treatment (pharmacotherapy)]
acute myocardial infarction
Kim IS et al. JACC Cardiovasc Interv. 2011
NM_000769.4:c.[681G>A;636G>A]
genomics
platelet reactivity[other]
acute myocardial infarction
Jeong YH et al. Circ Cardiovasc Interv. 2011
NM_000769.4:c.[681G>A;636G>A]
genomics
cardiovascular death;recurrent myocardial infarction;stroke[prognosis (bad)]
acute myocardial infarction
Jeong YH et al. Circ Cardiovasc Interv. 2011
NM_000769.4:c.[681G>A;636G>A]
genomics
acute type 4b myocardial infarction[diagnosis]
acute type 4b myocardial infarction
Wu H et al. Circ J. 2012
NM_000769.4:c.[681G>A;636G>A]
genomics
recurrent myocardial infarction[prognosis (bad)]
type 4b myocardial infarction
Xie X et al. PLoS One. 2013
NM_000769.4:c.[681G>A;636G>A]
genomics
death[prognosis (bad)]
type 4b myocardial infarction
Xie X et al. PLoS One. 2013
NM_000769.4:c.[681G>A;636G>A]
genomics
stent thrombosis[prognosis (bad)]
type 4b myocardial infarction
Xie X et al. PLoS One. 2013
NM_000769.4:c.[681G>A;636G>A;-806C>T]
genomics
prasugrel[treatment (pharmacotherapy)]
acute myocardial infarction
Lee JH et al. Platelets. 2016
cytochrome P450 2C19
proteomics
major adverse cardiac and cerebral events[prognosis (bad)]
acute myocardial infarction
Kim HS et al. Circ Cardiovasc Genet. 2013
NM_000769.4:c.681G>A
genomics
cardiovascular adverse events[prognosis (bad)]
myocardial infarction
Collet JP et al. Lancet. 2009
NM_000769.4:c.-806C>T
genomics
target lesion revascularization[prognosis (bad)]
acute myocardial infarction
Tiroch KA et al. Am Heart J. 2010
NM_000769.4:c.-806C>T
genomics
major adverse cardiovascular events[prognosis (bad)]
acute myocardial infarction
Tiroch KA et al. Am Heart J. 2010
NM_000769.4:c.681G>A
genomics
death[prognosis (bad)]
acute myocardial infarction
Maek LA et al. Cardiology. 2010
NM_000769.4:c.681G>A
genomics
major adverse cardiovascular events[prognosis (bad)]
myocardial infarction
Hulot JS et al. Circ Cardiovasc Interv. 2011
NM_000769.4:c.681G>A
genomics
death[prognosis (bad)]
acute myocardial infarction
Cresci S et al. Circ Cardiovasc Genet. 2014
NM_000769.4:c.-806C>T
genomics
death[prognosis (bad)]
acute myocardial infarction
Cresci S et al. Circ Cardiovasc Genet. 2014
NM_000769.4:c.-806C>T
genomics
hospital readmission[prognosis (bad)]
acute myocardial infarction
Depta JP et al. Pharmacogenomics J. 2015
NM_000769.4:c.681G>A
genomics
acute myocardial infarction[diagnosis]
acute myocardial infarction
Zhang M1 et al. J Cell Mol Med. 2016
NM_000769.4:c.681G>A
genomics
death[prognosis (bad)]
acute myocardial infarction
Zhang M1 et al. J Cell Mol Med. 2016
NM_000769.4:c.-889T>G
genomics
hemorrhage[prognosis (bad)]
acute ST elevation myocardial infarction
Novkovic M et al. Eur J Clin Pharmacol. 2018
NM_000769.4:c.681G>A
genomics
acute myocardial infarction[diagnosis]
acute myocardial infarction
Zhou WL et al. Platelets. 2019
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